{"id":16684,"date":"2024-10-28T10:22:52","date_gmt":"2024-10-28T10:22:52","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=news&#038;p=16684"},"modified":"2025-01-02T14:50:40","modified_gmt":"2025-01-02T14:50:40","slug":"achieving-speed-and-precision-reliable-activation-of-nachr-alpha-7","status":"publish","type":"news","link":"https:\/\/nanion.com\/ja\/news\/achieving-speed-and-precision-reliable-activation-of-nachr-alpha-7\/","title":{"rendered":"Achieving speed and precision: Reliable activation of nAChR alpha-7"},"content":{"rendered":"<div id=\"pl-16684\" class=\"panel-layout\"><div id=\"pg-16684-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-16684-0-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-16684-1\" class=\"panel-grid panel-no-style\"><div id=\"pgc-16684-1-0\" class=\"panel-grid-cell\"><div id=\"panel-16684-1-0-0\" class=\"so-panel widget widget_text panel-first-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><h4>Available on-demand. Watch now!<\/h4>\n<\/div>\n\t\t<\/div><div id=\"panel-16684-1-0-1\" class=\"so-panel widget widget_vido-lightbox-theme-widget\" data-index=\"1\"><div class=\"so-widget-vido-lightbox-theme-widget so-widget-vido-lightbox-theme-widget-default-d75171398898-16684\"><div class=\"video-lightbox\">\n                <div class=\"image\">\n                <div class=\"play-button\"><a href=\"https:\/\/youtu.be\/wdeG2_YGLlQ\" data-fancybox data-scrolling=\"no\"><\/a><\/div>\n                <noscript><img decoding=\"async\" width=\"2500\" height=\"1308\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand.png\" class=\"attachment-full size-full\" alt srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand.png 2500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-300x157.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-1024x536.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-768x402.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-1536x804.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-2048x1072.png 2048w\" sizes=\"(max-width: 2500px) 100vw, 2500px\"><\/noscript><img decoding=\"async\" width=\"2500\" height=\"1308\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202500%201308%22%3E%3C%2Fsvg%3E\" class=\"attachment-full size-full lazyload\" alt srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202500%201308%22%3E%3C%2Fsvg%3E 2500w\" sizes=\"(max-width: 2500px) 100vw, 2500px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand.png 2500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-300x157.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-1024x536.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-768x402.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-1536x804.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand-2048x1072.png 2048w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/2024_a7-nAChR-webinar_on-demand.png\">            <\/div>\n        <\/div><\/div><\/div><div id=\"panel-16684-1-0-2\" class=\"so-panel widget widget_sow-editor\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h4>Do you have any questions about the webinar?<\/h4>\n<h4>Feel free to reach out to us!<\/h4>\n<h4><a href=\"mailto:team.marketing@nanion.de\">] Contact us [<\/a><\/h4>\n<\/div>\n<\/div><\/div><div id=\"panel-16684-1-0-3\" class=\"so-panel widget widget_sow-editor\" data-index=\"3\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3>Explore related tools and resources:<\/h3>\n<p>&nbsp;<\/p>\n<ul>\n<li>The&nbsp;<strong>PrecisION\u2122 hnAChR \u03b17\/ric3 cell line<\/strong>&nbsp;offers reliable electrophysiological measurements of nAChR \u03b17\/ric3 activity.&nbsp;&nbsp;<a href=\"https:\/\/www.discoverx.com\/catalog\/precision-hnachr-alpha7-ric3-recombinant-stable-cell-line\/cyl3097\" target=\"_blank\" rel=\"noopener\">]&nbsp;Learn&nbsp;more&nbsp;[<\/a><\/li>\n<li>Our&nbsp;<strong>NPC-384 chips<\/strong>&nbsp;for SyncroPatch 384 enable high-throughput studies of ion channels, including fast ligand-gated and mechanosensitive channels.&nbsp;<a href=\"\/products\/syncropatch-384\/consumables\/\" target=\"_blank\" rel=\"noopener\">]&nbsp;Learn&nbsp;more&nbsp;[<\/a><\/li>\n<\/ul>\n<p>Want to explore the webinar slides?<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-16684-1-0-4\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-16684\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2024\/12\/2024_Nanion_Webinar_Achieving-speed-and-precision-Reliable-activation-of-nAChR-alpha-7_Slides-all-presentations.pdf\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tDownload here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-16684-2\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-16684-2\"><div id=\"pgc-16684-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-16684-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-16684-3\"><div id=\"pgc-16684-3-0\" class=\"panel-grid-cell\"><div id=\"panel-16684-3-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"5\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3>Agenda:<\/h3>\n<p>&nbsp;<\/p>\n<ol>\n<li>Introduction (Nanion Technologies)<\/li>\n<li><strong>James Costantin<\/strong> (DiscoverX\/Eurofins)<\/li>\n<li><strong>Ilka Rinke-Wei\u00df<\/strong> (Senior Scientist, Nanion Technologies)<\/li>\n<li>Joint discussion<\/li>\n<\/ol>\n<h3><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-16684-3-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"6\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>&nbsp;<\/p>\n<h3><span style=\"color: #000000;\">Summary<\/span><\/h3>\n<p>&nbsp;<\/p>\n<p>The \u03b17 subtype of nicotinic acetylcholine receptors (nAChR \u03b17) is integral to neurological and immune signaling, emerging as a promising therapeutic target for disorders such as Alzheimer\u2019s disease and schizophrenia. Yet, nAChR \u03b17 electrophysiological studies face significant technical challenges due to the receptor's rapid desensitization, low ion channel conductance, and limited availability of selective ligands. To address these, recent innovations include the development of a stable nAChR \u03b17\/ric3 HEK cell line by Eurofins\/DiscoverX, which improves receptor expression and enables enhanced acetylcholine response with positive allosteric modulators (PAMs) such as PNU-120596. These advancements help overcome receptor desensitization, allowing for more reliable assays.<\/p>\n<p>This webinar will highlight the benefits of using Ready-to-Assay (RTA) frozen cells from this stable line, which deliver consistent performance post-thaw, eliminating the need for live cell cultures. Validation data will show acetylcholine potentiation using two distinct PAMs, PNU-120596 and NS-1738, on the SyncroPatch 384 platform.<\/p>\n<p>Furthermore, Nanion Technologies introduces the NPC-384T F\/M STIM chip, engineered for the SyncroPatch 384 system to enhance the precision and speed of ligand applications critical for the reliable activation of fast-desensitizing ion channels like nAChR \u03b17. Compared to standard chips, F\/M STIM chips deliver superior performance with higher seal resistance, greater current amplitudes, and faster response kinetics, while maintaining consistency in EC50 values for ligands such as acetylcholine, nicotine, and the PAM PNU-120596.<\/p>\n<p>Join us to learn about these exciting developments in nAChR \u03b17 assays.<\/p>\n<p>Key insights will be presented by James Costantin from Eurofins\/DiscoverX, who will discuss the stable cell line advancements, and Ilka Rinke-Wei\u00df from Nanion Technologies, who will showcase the enhanced capabilities of the NPC-384T F\/M STIM chip on the SyncroPatch 384. These tools represent a significant leap forward in enabling high-throughput, reliable nAChR a7 pharmacological screening.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Available on-demand. Watch now! Do you have any questio [&hellip;]<\/p>\n","protected":false},"featured_media":16694,"template":"","news_categories":[528,13],"class_list":["post-16684","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-event"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/news\/16684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media\/16694"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=16684"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/news_categories?post=16684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}