Long-term exposure to cancer-related therapeutics has been linked to alterations of cardiac function in patients. The Stem Cell Working Group as part of the Health and Environmental
Science Institute (HESI) currently endeavors to gain further insight into chronic cardiotoxicity. The objective of the HESI study is to optimize non-clinical safety assessment strategies
of chronic cardiotoxicity by testing prolonged exposure of compounds on different cell-based assay systems using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), by investigating e.g. contractility or contractile force